“The data published in these journals are reflective of our in-depth understanding of the activity of NYX-2925, garnered through evaluations across numerous molecular and behavioral preclinical models,” remarked
The first publication is titled “NYX‐2925 induces metabotropic NMDAR signaling that enhances synaptic NMDAR and AMPAR” and has been published in the
The second publication is titled “NMDAR activation regulates the daily rhythms of sleep and mood” and has been published in Sleep. The data presented in this paper demonstrate the positive activity exhibited by NYX-2925 on various elements of sleep architecture.
The third publication is titled “A translational EEG-based approach to assess modulation of long-lasting NMDAR-dependent synaptic plasticity” and has been published in Psychopharmacology. Oral administration of NYX-2925 enhanced alpha power, increased NMDA receptor-dependent auditory LTP, and facilitated NMDA receptor-dependent mismatch negativity. The published studies are the first in vivo demonstration of the long-lasting effects of positive NMDA receptor modulation on synaptic plasticity processes using non-invasive EEG techniques.
NYX-2925 is a novel oral NMDA receptor modulator currently in Phase 2 clinical development for the treatment of chronic pain. In clinical studies, NYX-2925 has been shown to have activity that affects central pain processing, resulting in alleviation of pain and other symptoms associated with chronic pain conditions. In Phase 1 and Phase 2 clinical studies, NYX-2925 has exhibited a favorable safety and tolerability profile across a wide dose range. In preclinical models of numerous neuropathic pain conditions, NYX-2925 has shown robust activity with a favorable tolerability profile.
Aptinyx Inc. is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of proprietary synthetic small molecules for the treatment of brain and nervous system disorders. Aptinyx has a platform for discovery of novel compounds that work through a unique mechanism to modulate—rather than block or over-activate—NMDA receptors and enhance synaptic plasticity, the foundation of neural cell communication. The company has three product candidates in clinical development in central nervous system indications, including chronic pain, post-traumatic stress disorder, and cognitive impairment associated with Parkinson’s disease. Aptinyx is also advancing additional compounds from its proprietary discovery platform, which continues to generate a rich and diverse pipeline of small-molecule NMDA receptor modulators with the potential to treat an array of neurologic disorders. For more information, visit www.aptinyx.com.
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding the company’s business plans and objectives, therapeutic effects of the company’s product candidates, expectations regarding the design, implementation, timing, and success of its current and planned clinical studies, and expectations regarding its uses and sufficiency of capital. Risks that contribute to the uncertain nature of the forward-looking statements include: the success, cost, and timing of the company’s product candidate development activities and planned clinical studies; the company’s ability to execute on its strategy; positive results from a clinical study may not necessarily be predictive of the results of future or ongoing clinical studies; regulatory developments in
Source: Aptinyx Inc.